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Within our study, we ended up able to appreciably escalate the dose of CX-5461 past that reached in the primary-in-human study in clients with hematologic cancers. The RP2D of 475 mg/m2 on times 1, eight, and 15 of the 4-7 days cycle, was based upon phototoxicity, which transpired Irrespective of stringent UV gentle avoidance protocols and inside